Is Aminosalicylic Acid safe while breastfeeding?

Summary of use during breastfeeding

Limited information indicates that maternal aminosalicylic acid therapy produces low levels in milk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored for rare instances of jaundice, gastrointestinal disturbances, hypokalemia, thrombocytopenia, hemolysis and hypokalemia if this drug is used during lactation.[1]

Effects on the breastfed infant

Aminosalicylic acid was used as part of multi-drug regimens to treat 2 pregnant women with multidrug-resistant tuberculosis throughout pregnancy and postpartum. Their two infants were breastfed (extent and duration not stated). At age 1.8 and 4.6 years, the children were developing normally, except for except for a mild speech delay in one at age 1.8 years, and failure to thrive in the other, possibly due to tuberculosis contracted after birth.[2]

Effects on milk supply

Relevant published information was not found as of the revision date.

Levels in milk

Maternal Levels. One woman who was lactating, but not breastfeeding (time postpartum not stated) took a single 4 gram oral dose of aminosalicylic acid. A peak milk level of 1.1 mg/L occurred 3 hours after the dose. The drug's half-life in milk was estimated to be 2.5 hours.[1] Using these data, a fully breastfed infant would receive a maximum of about 0.25% of the maternal weight-adjusted dosage.

Infant Levels. Relevant published information was not found as of the revision date.