Is Anidulafungin safe while breastfeeding?
Here is what LactMed, the Drugs and Lactation Database published by the U.S. National Institute of Child Health and Human Development (NICHD), reports about Anidulafungin. The text below is quoted from that source — it is not our own verdict.
Summary of use during breastfeeding
Because of the low levels of anidulafungin in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. If anidulafungin is required by the mother, it is not a reason to discontinue breastfeeding.
Effects on the breastfed infant
A postpartum woman was treated with intravenous anidulafungin 100 mg once daily for 14 days. She withheld breastfeeding until the second day after completing her 14-day course of therapy. Her milk had detectable anidulafungin levels until 32 hours after the last dose. No gastrointestinal or other adverse effects were seen in the infant up to 72 hours after the last dose of drug.[1]
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. A postpartum woman was treated with intravenous anidulafungin 100 mg once daily for 14 days. Nine milk samples were obtained over the first 32 hours after the drug was discontinued. Five hours after drug was discontinued, the milk concentration of anidulafungin was 0.24 mg/L. The concentration decreased to 0.12 mg/L at 32 hours after the dose and was undetectable in milk at 38 and 48 hours after the dose.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Alternatives LactMed lists
Source: Drugs and Lactation Database (LactMed), National Institute of Child Health and Human Development (NICHD), via NCBI Bookshelf, record “Anidulafungin” (anidulafungin). LactMed on NCBI Bookshelf. LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.