Is Biperiden safe while breastfeeding?
Here is what LactMed, the Drugs and Lactation Database published by the U.S. National Institute of Child Health and Human Development (NICHD), reports about Biperiden. The text below is quoted from that source — it is not our own verdict.
Summary of use during breastfeeding
Biperiden is no longer marketed in the United States. No information is available on the use of biperiden during breastfeeding. Long-term use of biperiden might reduce milk production or milk letdown, but a single dose is not likely to interfere with breastfeeding. During long-term use, observe for signs of decreased lactation (e.g., insatiety, poor weight gain).
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
In a study in 5 healthy nonlactating subjects (3 male, 2 female), 5 mg of biperiden was infused intravenously over 2 hours. Serum prolactin was measured 7 times during the infusion and two times afterwards. Although the average serum prolactin value deceased slightly by 120 minutes, the difference was not statistically significant. The average serum prolactin rebounded to approximately baseline at 2 hours after the end of the infusion.[1]
Levels in milk
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Source: Drugs and Lactation Database (LactMed), National Institute of Child Health and Human Development (NICHD), via NCBI Bookshelf, record “Biperiden” (biperiden). LactMed on NCBI Bookshelf. LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.