Is Eplontersen safe while breastfeeding?
Here is what LactMed, the Drugs and Lactation Database published by the U.S. National Institute of Child Health and Human Development (NICHD), reports about Eplontersen. The text below is quoted from that source — it is not our own verdict.
Summary of use during breastfeeding
No information is available on the use of eplontersen during breastfeeding. Because eplontersen has a molecular weight of 9046 Da and is over 98% bound to plasma proteins, the amounts in milk are likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal. But its half-life is long, so it could accumulate in the infant. If a mother requires eplontersen, it is not a reason to discontinue breastfeeding. Until more data become available, eplontersen should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. Monitor the breastfed infant for vomiting and possible vitamin A deficiency.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
“No published information” means the studies do not exist yet — not that Eplontersen is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: Drugs and Lactation Database (LactMed), National Institute of Child Health and Human Development (NICHD), via NCBI Bookshelf, record “Eplontersen” (eplontersen). LactMed on NCBI Bookshelf. LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.