Is Rimegepant safe while breastfeeding?
Here is what LactMed, the Drugs and Lactation Database published by the U.S. National Institute of Child Health and Human Development (NICHD), reports about Rimegepant. The text below is quoted from that source — it is not our own verdict.
Summary of use during breastfeeding
No information is available on the clinical use of rimegepant during breastfeeding. However, amounts in breastmilk are low and would not be expected to cause any adverse effects in breastfed infants. Some experts recommend withholding breastfeeding for 8 to 12 hours after a dose, although this seems to be too conservative given the small amounts in milk.[1] If rimegepant is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred while nursing a newborn or preterm infant.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. Twelve healthy women volunteers between 2 an6 6 months postpartum were given a single dose of 75 mg of rimegepant orally. Milk samples from complete emptying of both breasts were obtained 15 to 30 minutes before the dose and 1, 2, 4, 8, 12, 16, 24, 32, and 36 hours after the dose. Peak milk rimegepant levels averaged 169.6 mcg/L at an average of 2 hours after the dose. Average milk levels over the first 24 hours after the dose was 34 mcg/L, which translated into an average daily infant dose of 0.005 mg/kg or a relative infant dose of 0.51%.[2]
Infant Levels. Relevant published information was not found as of the revision date.
Alternatives LactMed lists
“No published information” means the studies do not exist yet — not that Rimegepant is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: Drugs and Lactation Database (LactMed), National Institute of Child Health and Human Development (NICHD), via NCBI Bookshelf, record “Rimegepant” (rimegepant). LactMed on NCBI Bookshelf. LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.