Can I take Xanomeline while breastfeeding?

Is Xanomeline safe while breastfeeding?

Here is what LactMed, the Drugs and Lactation Database published by the U.S. National Institute of Child Health and Human Development (NICHD), reports about Xanomeline. The text below is quoted from that source — it is not our own verdict.

Summary of use during breastfeeding

Xanomeline is a cholinergic antipsychotic agent that is available in combination with trospium, which is a peripheral anticholinergic agent. No information is available on the clinical use of xanomeline or trospium during breastfeeding. Because trospium is a charged molecule, it is unlikely to pass well into milk. If the mother requires xanomeline, it is not a reason to discontinue breastfeeding. Until more data are available, the xanomeline-trospium combination should only be used with careful infant monitoring, particularly for gastrointestinal side effects such as nausea, vomiting diarrhea, and reflux.

Effects on the breastfed infant

Relevant published information was not found as of the revision date.

Effects on milk supply

Relevant published information was not found as of the revision date.

Levels in milk

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

“No published information” means the studies do not exist yet — not that Xanomeline is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.

Source: Drugs and Lactation Database (LactMed), National Institute of Child Health and Human Development (NICHD), via NCBI Bookshelf, record “Xanomeline” (xanomeline). LactMed on NCBI Bookshelf. LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.