Is Zavegepant safe while breastfeeding?
Here is what LactMed, the Drugs and Lactation Database published by the U.S. National Institute of Child Health and Human Development (NICHD), reports about Zavegepant. The text below is quoted from that source — it is not our own verdict.
Summary of use during breastfeeding
Because of the low levels of zavegepant in breastmilk after intranasal administration, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.
Effects on the breastfed infant
Relevant published information was not found as of the revision date.
Effects on milk supply
Relevant published information was not found as of the revision date.
Levels in milk
Maternal Levels. Twelve healthy lactating women who were at least 2 weeks postpartum were give a single intranasal dose of 10 mg of zavegepant. Milk samples were taken before the dose and at 0 to 2, 2 to 4, 4 to 6, 6 to 8, 8 to 12, 12 to 16, and 16 to 24 hours after the dose. The median peak milk concentration was 1.10 mcg/L, and the geometric mean peak concentration was 0.77 mcg/L at a median of 4.83 hours after the dose. The estimated infant daily dosage was 0.05 to 0.06 mcg/kg, which resulted in an RID of 0.04 to 0.05%.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Alternatives LactMed lists
“No published information” means the studies do not exist yet — not that Zavegepant is known to be harmful, and not that it is known to be safe. Your prescriber or pharmacist can weigh your baby's age and whether a better-studied alternative would do the same job. Worth asking before stopping a medicine you need.
Source: Drugs and Lactation Database (LactMed), National Institute of Child Health and Human Development (NICHD), via NCBI Bookshelf, record “Zavegepant” (zavegepant). LactMed on NCBI Bookshelf. LactMed is a registered trademark of the U.S. Department of Health and Human Services.
Educational summary of an authoritative source — not medical advice. Never start, stop, or change a medicine while breastfeeding without confirming with your doctor.